Scientists Just Identified a Molecule at the Core of Exercise-Driven Longevity - and It’s Been Inside NoxShot™ From the Very Beginning

Scientists Just Identified a Molecule at the Core of Exercise-Driven Longevity - and It’s Been Inside NoxShot™ From the Very Beginning (NoxShot™) our trademarked active ingredient complex based on beetroot-derived bioactive nitrogen intermediates. The underlying mechanism of our supplements AURA and RA. 

For decades, researchers have tried to answer a deceptively simple question:

Why does exercise slow aging so effectively?

We’ve known the effects - better muscle strength, sharper cognition, stronger immunity, reduced inflammation - but not the master switch behind it.

Now a multidisciplinary team of scientists studying long-term exercise has uncovered a surprising molecular candidate. Published in Cell and reported widely, the findings point to a humble, naturally occurring compound:

Betaine.

Yes - betaine (trimethylglycine, TMG) - a methyl-donor molecule synthesized primarily in the renal mitochondria via the oxidation of choline by choline dehydrogenase (CHDH) during sustained aerobic exercise. It accumulates as part of the body’s adaptive metabolic response. Betaine is also naturally abundant in Beta vulgaris (beetroot), where it exists as a key osmolyte supporting the plant’s nitrate-rich physiology.

Betaine (trimethylglycine, TMG) joins the natural Nitrate–Nitrite–Nitric Oxide (NNN) pathway found in beetroot to form a complete nitrogen-axis system: vascular nitrogen (NO₃⁻ → NO₂⁻ → NO) combined with methylation nitrogen (TMG → BHMT → SAM). This dual nitrogen architecture underpins the biological activity of NoxShot™. Not added artificially. Not sprinkled in for marketing. It has been there since the day one - because it is part of the biological foundation of what NoxShot™ is built on.

Let’s break down what scientists found, and why this discovery matters.

The Study: What Happens Inside the Body During Long-Term Exercise

A 2024 study conducted over six years followed healthy adults and performed deep metabolic, immune, and molecular profiling during single bouts of exercise versus long-term training.(Reference: Cell Press summary)

The core finding:

During consistent exercise, the kidneys massively increase production of betaine, which enters circulation and acts as a systemic anti-inflammatory and metabolic regulator.

This wasn’t speculation — the study identified a clear mechanistic pathway:

Kidney → Betaine ↑ → TBK1 inhibition → Inflammation ↓ → Mitochondrial function ↑

The key target, TBK1 (TANK-binding kinase 1), is a driver of chronic inflammation and age-related decline.Betaine directly inhibits TBK1, dampening the inflammatory cascade involving IRF3 and NF-κB - two well-characterized signaling pathways in immunology and aging research.

Supporting evidence: The same mechanism was confirmed in vivo - supplementing aged mice with betaine improved muscle strength, liver and kidney health, cognitive function, and markers of cellular senescence.(Source: Chen et al., Cell Research / Cell Press reports)

Combine that with previous literature showing betaine supports methylation, vascular health, and mitochondrial efficiency and the picture becomes clear:

Betaine is not just a nutrient, It is one of the molecular signatures of the “exercise state.” NoxShot™ Has Delivered Betaine From the Start

Our core formula includes 16 grams of beetroot juice concentrate per shot. (in current version of AURA & RA supplements)

Beets are naturally rich in:

• Dietary nitrates → nitric oxide and vascular benefits

• Betaine → the molecule now highlighted as an exercise-linked anti-aging signal

Independent nutritional analyses of high-quality beet juice powders confirm betaine concentrations around 0.47–0.50% by weight (Reference: nutritional analysis from beetroot juice powders).

That means:

Each NoxShot™ delivers approximately 75–80 mg of natural betaine per serving.

This isn’t a fortified ingredient. It’s not an additive. It’s the physiological backbone of beet biochemistry - the same biochemistry athletes, researchers, and now longevity scientists are rediscovering.

It is just happened so, that we have built the product around the natural biology from the start.

Why This Matters:? NoxShot™ Works Through the Same Biological Axes the New Research Highlights

The newly discovered exercise-longevity mechanism is:

Betaine → TBK1 inhibition → Reduced inflammaging → AMPK/SIRT1 → Mitochondrial rejuvenation

NoxShot™ naturally aligns with this, and not only because of betaine.

The NoxShot™ base formula includes:

• Beet nitrates → improved nitric oxide signaling

• Rhodiola rosea → AMPK activation and mitochondrial support

• Sunflower lecithin → phospholipid repair and membrane health

• Collagen + vitamin C + zinc → connective tissue resilience

• Dandelion root → liver & kidney axis support (exactly the organ that produces betaine during exercise)
  

The system that scientists say is central to the anti-aging effects of exercise - the kidney–betaine–inflammation–mitochondria axis - is the same integrated network that NoxShot™ supports through design, not coincidence.

Let’s Be Clear About What We. Do Not Claim

We do not claim NoxShot™ replaces exercise and obviusly we do not claim betaine supplementation has proven anti-aging effects in humans.

The new research is early and mostly based on:

• mechanistic human data

• rodent models

• cell studies
  

But what is clear and fully supported by the literature is this:

Betaine is a central metabolic signal in the biology of exercise.

Beets are one of the richest natural sources of betaine.

NoxShot™ is built on high-potency beetroot concentrate, delivering real, measurable betaine doses.

And that is a scientific fact, not a marketing phrase.

The Bottom Line

Scientists went looking for the molecular essence of exercise.They found betaine - a molecule that calms inflammation, supports mitochondrial health, and is produced by the kidneys during sustained training.

NoxShot™ has been delivering this molecule - naturally, consistently, and in meaningful dietary amounts - since the very beginning.

Sometimes innovation comes from being ahead and sometimes innovation comes from simply trusting biology.

In our case, it’s both.

Key References:

• Schwab et al. American Journal of Clinical Nutrition (2002). Homocysteine reduction via betaine. doi:10.1093/ajcn/76.5.961

• Chen et al. Cell Research (2024). Betaine as a regulator of TBK1 and inflammaging. (via Cell Press)

• Steenge et al. Am J Physiol Endocrinol Metab (2001). Creatine synthesis & methylation. doi:10.1152/ajpendo.2001.281.5.E1095

• Studies on dietary nitrate and beetroot performance effects: Kapil et al., Heart (2020). doi:10.1136/heartjnl-2020-317433